| Abstrakt: |
This document is an editorial published in Frontiers in Endocrinology titled "Double-edged swords: important factors connecting metabolic disorders and cancer development -- from basic research to translational applications, volume II." The editorial discusses the intersection between metabolic dysfunction and cancer development, highlighting new challenges and opportunities in this field. It covers various topics such as drug resistance in cancer therapy, strategies to overcome resistance in hepatocellular carcinoma, the role of immunity and metabolism in liver steatosis-driven carcinogenesis, the link between metabolic factors and thyroid cancer, the role of metabolites in kidney tubulogenesis, the role of glucose metabolism in human diseases, genetic alterations in metabolic enzymes and their contribution to diseases, the potential therapeutic target of MG53 in cancer, the potential of niclosamide in cancer therapy, and the role of innate immunity and inflammation in differential susceptibilities to metabolic disorders and cancer among racial populations. The editorial concludes by emphasizing the ongoing discussion and learning about the links between metabolic functions and cancer, from basic science to translational applications. [Extracted from the article] |
