Toxicity and Antihypoxic Activity of a Preparation Containing a Complex Compound of 5-Hydroxy-6-Methyluracil with N-Acetyl Cysteine.

Autor: Kutlugildina, G. G., Zimin, Yu. S., Gimadieva, A. R., Repina, E. F., Kudoyarov, E. R.
Předmět:
Zdroj: Pharmaceutical Chemistry Journal; May2024, Vol. 58 Issue 2, p175-179, 5p
Abstrakt: 5-Hydroxy-6-methyluracil (5-OH-6-MU) was shown to form a 1:1 complex with N-acetylcysteine (N-AC), i.e., the compounds interacted in an equimolar ratio. The temperature dependence of the stability constant was studied in the range 291-316 K. The thermodynamic parameters of the complexation process were determined. Aprocedure for the synthesis of the 5-OH-6-MU...N-AC complex was developed based on the results. The toxicity and antihypoxic activity of the complex were subsequently studied. The synthesized compound at a dose of 500 mg/kg in mice had low toxicity and antihypoxic activity significantly superior to those of the reference drugs (5-OH-6-MU and N-AC). [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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