| Autor: |
Figura, Monika, Przytycka, Joanna, Dzierzęcki, Sebastian, Szumilas, Mateusz, Szlufik, Stanisław, Milanowski, Łukasz, Kłoda, Maria, Duszyńska-Wąs, Karolina, Kowalska-Taczanowska, Renata, Drzewińska, Agnieszka, Sadowski, Karol, Korn, Aleksandra, Ziobro, Anna, Bochniak, Katarzyna, Friedman, Andrzej, Ząbek, Mirosław, Koziorowski, Dariusz |
| Předmět: |
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| Zdroj: |
Polish Journal of Neurology & Neurosurgery / Neurologia i Neurochirurgia Polska; 2024, Vol. 58 Issue 3, p283-291, 9p |
| Abstrakt: |
Introduction. Unilateral gamma knife thalamotomy (GKT) is a treatment option for pharmacoresistant tremor of various aetiologies. There have been to date no randomised controlled trials performed to assess its safety and efficacy. Our aim was to summarise a two-year multimodal observation of patients with tremor caused by Parkinson's Disease (PD) or essential tremor (ET). Material and methods. 23 patients with PD (n = 12) or ET (n = 11) were included. They underwent assessments before, V0 (n = 23), and 12 months, V12 (n = 23), and 24 months, V24 (n = 15), after unilateral GKT. Patients were assessed with psychological tests and acoustic voice analysis. Tremor assessment was performed with a digitising table using the Fahn-Tolosa-Marin rating scale (FTMRS). The Unified Parkinson's Disease rating scale part III (UPDRS-III) was also used in the PD group. Gait and balance was assessed using clinical tests, stabilometric platform, and treadmill. Results. No side effects were observed in a two-year follow-up. There was no notable deterioration observed in the patients' psychological evaluation, speech, or assessment of gait and balance. The scores were significantly lower (p = 0.01) in parts A and B of FTMRS one year after GKT. In post hoc analysis, the scores did not differ significantly between V0 and V24. In FTMRS part C (activities of daily living), no significant change was observed. There was no significant difference in total UPDRS part III score or in score of UPDRS part III domains 3 and 4 ('tremor at rest' and 'action and postural tremor of hands') between measurements. Conclusions. UGKT may be a safe treatment modality if performed in an experienced centre. Tremor reduction may diminish over time, and UGKT did not lead to cognitive, gait or speech deterioration in a long-term observation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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