| Abstrakt: |
Simple Summary: There are many causes of discospondylitis (infection in the discs and neighboring bones in the vertebral column), and it can be difficult to identify the relevant infection in all cases. In this study, we report the diseases we detected after recommending a specific series of tests to owners of affected dogs in this Brucella canis endemic region of the world. We found a moderate proportion (~12%) of cases that had Brucella canis infection (which is infectious to people) and suspected fungal infection (which can be very difficult to treat). Blood cultures were frequently (39%) positive for an infectious agent. The outcome for most cases, even those with suspected fungal disease, was good. It appears that blood culture is a helpful diagnostic method, and stabilizing implants can be safely used even when there is bone infection. Our results suggest that both fungal and Brucella spp. infections may be moderately common causes of discospondylitis in dogs in the USA, where Brucella canis is endemic. Discospondylitis is a well-recognized disease in dogs, but the relative prevalence of causal infectious agents and efficiency of relevant diagnostic tests are not well-established. Medical record review identified 117 dogs diagnosed with discospondylitis in our clinic over a 5-year period. In 32 dogs, discospondylitis was diagnosed as an incidental imaging finding; 24 of these dogs had concomitant neoplasia. A likely causal infection was identified in 45 of the remaining 85 dogs in which blood and urine cultures, serology for Brucella spp., and galactomannan fungal antigen testing were recommended. Ten dogs were diagnosed with Brucella canis, and ten were diagnosed with suspected fungal infection. Brucella suis serology was negative in all 35 dogs that were tested. Blood cultures were positive in 28 of 71 (39%) tested dogs, and urine culture was positive in 12 of 79 (15%). Cultures were positive from the lesion site of four of eight dogs that underwent surgery and one of the five dogs that underwent image-guided lesion sample collection. Subluxation secondary to discospondylitis was stabilized with metallic implants in four dogs. A similar proportion of known satisfactory treatment outcomes at last follow-up were recorded in dogs that had suspected fungal disease, other bacterial infections, or were Brucella-positive and in those dogs with imaging diagnosis only, although some individuals continued to receive anti-microbial agents or showed recurrent signs. These data support the value of blood culture in discospondylitis and suggest a relatively high prevalence of infection with Brucella spp. and suspected fungal infection. [ABSTRACT FROM AUTHOR] |
