| Autor: |
Yu, Jiaming, Guo, Hui, Zhang, Jing, Hu, Jiansen, He, Hongtao, Chen, Caixia, Yang, Na, Yang, Fan, Lin, Zexu, Dai, Huanqin, Ouyang, Liming, Liu, Cuihua, Lei, Xiaoguang, Zhang, Lixin, Zhu, Guoliang, Song, Fuhang |
| Zdroj: |
Marine Drugs; Jun2024, Vol. 22 Issue 6, p259, 11p |
| Abstrakt: |
A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
