High-level expression of chromosomally encoded SHV-1 β-lactamase reduces the susceptibility to cefiderocol of clinical isolates of Klebsiella pneumoniae.

Autor:	Charfi, Rym, Tazi, Asmaa, Sereme, Youssouf, Plainvert, Céline, Poupet, Hélène, Doloy, Alexandra, Guyonnet, Cécile, Morand, Philippe, Loubinoux, Julien, Poyart, Claire, Mammeri, Hedi
Předmět:	KLEBSIELLA pneumoniae GENE expression ENCODING GENETIC transcription
Zdroj:	Journal of Antimicrobial Chemotherapy (JAC); Jul2024, Vol. 79 Issue 7, p1711-1714, 4p
Abstrakt:	This document presents a study on the resistance mechanisms of Klebsiella pneumoniae to the antibiotic cefiderocol. The study focused on the overproduction of the SHV-1 β-lactamase in K. pneumoniae, which can reduce susceptibility to ceftazidime. The researchers sequenced and tested five clinical isolates of K. pneumoniae and found that those with SHV-1 overproduction exhibited resistance to cefiderocol. The study also identified a specific substitution in SHV-1 that enhanced its hydrolytic activity against cefiderocol. These findings contribute to our understanding of antibiotic resistance in K. pneumoniae and can help inform strategies to combat it. [Extracted from the article]
Databáze:	Complementary Index
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