Exploring the Role of the Gut Microbiota in Colorectal Cancer Development.
| Autor: | Ionescu, Vlad Alexandru, Gheorghe, Gina, Georgescu, Teodor Florin, Buica, Vlad, Catanescu, Mihai-Stefan, Cercel, Iris-Andreea, Budeanu, Beatrice, Budan, Mihail, Bacalbasa, Nicolae, Diaconu, Camelia |
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| Předmět: |
RISK assessment
LIFESTYLES ADENOMATOUS polyps BEHAVIOR modification GUT microbiome CELL proliferation EARLY detection of cancer SEX distribution COLORECTAL cancer IMMUNE system TUMOR markers GENES INFLAMMATORY bowel diseases HEALTH behavior CARCINOGENS CELL differentiation GENETIC mutation BACTERIAL diseases DIET DISEASE risk factors |
| Zdroj: | Gastrointestinal Disorders; Jun2024, Vol. 6 Issue 2, p526-537, 12p |
| Abstrakt: | Colorectal cancer is currently a public health concern due to its high incidence, morbidity, and mortality rates. Researchers have identified the intestinal microbiome as a crucial factor in the development of this disease. Currently, specialized literature data support the role of the microbiota in both the development of colorectal cancer and resistance to oncological therapies. Therefore, studying the composition of the gut microbiome can aid in creating risk assessment tools to identify specific populations that would benefit from tailored screening approaches. Also, manipulation of the intestinal microbiome can be useful in improving the response to chemotherapy or immunotherapy. Identifying the pathogenic mechanisms responsible for this causal link can aid in the discovery of novel treatment targets. This article will provide the latest information regarding the influence of the intestinal microbiota on the development and progression of colorectal cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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