| Autor: |
Ge, Chang, Qiao, Lipeng, Zhang, Yuyang, Sun, Kai, An, Jiangzhen, Peng, Mei, Chen, Xiaolan, Qu, Lingbo, Yu, Bing |
| Předmět: |
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| Zdroj: |
Chinese Journal of Chemistry; Aug2024, Vol. 42 Issue 15, p1679-1685, 7p |
| Abstrakt: |
Comprehensive Summary: A novel and eco‐friendly electrochemical activation of trifluoromethyl thianthrenium triflate (TT–CF3+OTf−) for trifluoromethylation of imidazole‐fused heteroaromatic compounds was established. This method involves the direct electrolysis of TT–CF3+OTf− without the requirement of external oxidants or catalysts, aligning with the principles of green chemistry. A wide range of imidazole‐fused heteroaromatic compounds including imidazo[1,2‐a]pyridines and benzo[d]imidazo[2,1‐b]thiazoles have been successfully trifluoromethylated using this technique, exhibiting excellent compatibility with various functional groups and a broad substrate scope. Moreover, the method's applicability for one‐pot sequential reactions enables the reduction of waste and resource consumption by eliminating the need for intermediate purification steps. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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