| Autor: |
George, Christine Marie, Namunesha, Alves, Felicien, Willy, Endres, Kelly, Luo, Wensheng, Bisimwa, Lucien, Williams, Camille, Bisimwa, Jean‐Claude, Sanvura, Presence, Perin, Jamie, Bengehya, Justin, Maheshe, Ghislain, Sack, David A., Cikomola, Cirhuza, Mwishingo, Alain |
| Předmět: |
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| Zdroj: |
Tropical Medicine & International Health; Jul2024, Vol. 29 Issue 7, p594-598, 5p |
| Abstrakt: |
Objective: Globally, there are estimated to be 2.9 million cholera cases annually. Early detection of cholera outbreaks is crucial for resource allocation for case management and for targeted interventions to be delivered to stop the spread of cholera. In resource limited settings such as Eastern Democratic Republic of the Congo (DRC), there is often limited laboratory capacity for analysing stool samples for cholera by bacterial culture. Therefore, rapid diagnostic tests (RDTs) for cholera present a promising tool to rapidly test stool samples in a health facility setting for cholera. Our objective is to evaluate the Crystal VC O1 RDT for cholera detection compared with bacterial culture and polymerase chain reaction (PCR) for Vibrio cholerae. Methods: From March 2020 to December 2022, stool samples were collected from 644 diarrhoea patients admitted to 94 health facilities in Bukavu in Eastern DRC. Patient stool samples were analysed by Crystal VC O1 RDT for cholera and by bacterial culture and PCR for V. cholerae O1. Results: Twenty six percent of diarrhoea patients (166/644) had stool samples positive for cholera by RDT, and 24% (152/644) had stool samples positive for V. cholerae O1 by bacterial culture or PCR. The overall specificity and sensitivity of the Crystal VC O1 RDT by direct testing was 94% (95% confidence interval [CI]: 92%–96%) and 90% (95% CI, 84%–94%), respectively, when compared with either a positive result by bacterial culture or PCR. Conclusion: Our findings suggest that the Crystal VC O1 RDT presents a promising tool for cholera surveillance in this cholera endemic setting in sub‐Saharan Africa. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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