Pediatric Diabetic Ketoacidosis: A Retrospective Study on Triggering Factors and Complications in a Turkish Intensive Care Unit.

Autor:	Aşık, Ayşe, Ermaydan, Meltem, Demir, Ayşe Şevval, Duyu, Muhterem
Předmět:	MEDICAL protocols PEARSON correlation (Statistics) RISK assessment T-test (Statistics) MULTIPLE organ failure DISEASE management DIABETIC acidosis SYMPTOMS SEVERITY of illness index TREATMENT effectiveness RETROSPECTIVE studies MANN Whitney U Test DESCRIPTIVE statistics PEDIATRICS CAREGIVERS HYPERGLYCEMIA INTENSIVE care units MEDICAL records ACQUISITION of data SEPSIS ONE-way analysis of variance SOCIODEMOGRAPHIC factors DATA analysis software EARLY diagnosis DIABETES NONPARAMETRIC statistics ACIDOSIS EVALUATION DISEASE risk factors DISEASE complications CHILDREN
Zdroj:	Journal of Pediatric Research; Jun2024, Vol. 11 Issue 2, p103-109, 7p
Abstrakt:	Aim: Diabetic ketoacidosis (DKA) is a critical, potentially life-threatening complication of diabetes mellitus (DM) in children, characterized by hyperglycemia, acidosis, and ketonemia/ketonuria. Despite its known risk factors and mortality rates, few studies have focused on the pediatric population, especially in specific regions under standard treatment protocols. This study investigated the demographic, clinical, and laboratory characteristics of children with DKA, identified its triggering factors, the factors affecting DKA severity and its complications, as well as evaluating the outcomes of a standardized treatment protocol in a Turkish pediatric intensive care unit (PICU). Materials and Methods: In this single-center retrospective study at Göztepe Prof. Dr. Süleyman Yalçın City Hospital's PICU, we included 115 children diagnosed with DKA between 2015 and 2022, following the DKA Treatment Protocol of the Turkish Society of Pediatric Emergency and Intensive Care Medicine and the International Society for Pediatric and Adolescent Diabetes guidelines. We analyzed the patients' demographic, clinical, and laboratory characteristics, treatment outcomes, and their complications using SPSS 25.0. Results: The sample primarily consisted of female patients and those newly diagnosed with DM, with a median age of 110 months. The mortality rate was low at 0.87%, with one death due to sepsis-induced multiple organ failure. DKA severity (lower GCS, younger age, electrolyte imbalance, acidosis, complications) correlated with longer PICU stays and recoveries in the children. The findings also highlighted the standardized treatment protocol's effectiveness in managing DKA and reducing complications. Conclusion: This study underscores the importance of early diagnosis, standardized treatment protocols, and comprehensive care in pediatric DKA management. It emphasizes the need for ongoing education and awareness among healthcare providers and caregivers in order to prevent DKA and its severe outcomes. Further multicenter studies are necessary to extend these findings to the broader pediatric population and refine DKA management strategies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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