| Autor: |
Ninomiya, André Felipe, Bertolucci, Vanessa, Kaneko, Luisa Oliveira, Nonose, Nilson, Abreu, Luiza di Loreto, Harfuch, Gabriel Rodrigues, dos Reis, Ivan Gustavo Masselli, Scariot, Pedro Paulo Menezes, Messias, Leonardo Henrique Dalcheco |
| Předmět: |
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| Zdroj: |
Biology (2079-7737); Jun2024, Vol. 13 Issue 6, p407, 18p |
| Abstrakt: |
Simple Summary: Fractures in the long bones are common injuries caused by accidents. This study looked at how these injuries heal after surgery. Two factors were checked: a substance in the blood called alkaline phosphatase and X-rays of the leg. After surgery, we found that the level of alkaline phosphatase went up, representing the bone healing. Along with this result, the X-rays also suggested the same information, that is, bone healing. We consider that by checking both the blood and the X-rays, doctors can better understand how leg bones heal after surgery. However, further studies with more patients are necessary to confirm this finding. Background/Objectives: Tibial diaphysis fractures are common injuries resulting from high-to-low-energy traumas in patients of all age groups, but few reports currently provide complementary parameters for the assessment of bone healing processes in the postoperative period. Serum alkaline phosphatase (ALP) and the scores from the Radiographic Union Scale for Tibial Fractures (RUST) can promote new horizons in this context. Therefore, the aim of this study was to assess the behavior of ALP and RUST through within-subject comparisons from immediately post-surgery to 49 days after tibial diaphysis fracture repair. Methods: This article included four case studies where patients underwent the same procedures. Adults of both sexes aged 18 to 60 years with tibial fractures requiring surgery were included. After surgical intervention (T1), the patients were followed for 49 days after surgery, returning for follow-up appointments on the 21st (T2) and 49th (T3) days. At the follow-up appointments, new X-ray images were obtained, and blood samples were collected for ALP measurement. Results: Serum ALP levels increased by T2 following tibial reamed intramedullary nailing surgery. While this increase persisted into T3 for two patients, a decline was observed during the same period for the other two patients. Both events are indicative of the bone consolidation process, and RUST scores at the T3 corroborate this perspective for all patients included in this study. Considering that delta ALP (T3-T1 value) was lower in patients who exhibited the highest RUST score, we suggest that a synchronized analysis between ALP and RUST allows medics to diagnose bone consolidation. Conclusions: Therefore, it can be concluded that the analysis of ALP alongside RUST may be complementary for evaluating bone consolidation following tibial reamed intramedullary nailing surgery, but future studies are needed to confirm this assertion. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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