Evaluation of the Relationship between Pain Exposure and Somatosensory Evoked Potentials in Preterm Infants: A Prospective Cohort Study.
| Autor: | Coviello, Caterina, Lori, Silvia, Bertini, Giovanna, Montano, Simona, Gabbanini, Simonetta, Bastianelli, Maria, Cossu, Cesarina, Cavaliere, Sara, Lunardi, Clara, Dani, Carlo |
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RISK assessment
SOMATOSENSORY evoked potentials T-test (Statistics) NEURAL development NEONATAL intensive care units DESCRIPTIVE statistics CHI-squared test MULTIVARIATE analysis NEONATAL intensive care SURGICAL complications LONGITUDINAL method DURATION of pregnancy PAIN PAIN management ARTIFICIAL respiration BRAIN injuries DATA analysis software CONFIDENCE intervals REGRESSION analysis AUDITORY evoked response COGNITION DISEASE risk factors |
| Zdroj: | Children; Jun2024, Vol. 11 Issue 6, p676, 13p |
| Abstrakt: | Background and aim: First, to compare somatosensory evoked potentials (SEPs) in preterm newborns without major brain injury studied at term equivalent age (TEA) with a term historical control group. Second, to investigate the impact of pain exposure during the first 28 days after birth on SEPs. Third, to evaluate the association between SEPs and Bayley-III at 2 years corrected age (CA). Methods: Infants born at <32 weeks' gestational age (GA) were studied with continuous-SEPs. First, SEP differences between preterm and term infants were analyzed. Second, regression analyses were conducted to explore the association between SEPs and painful procedures, and then between SEPs and neurodevelopment. Results: 86 preterm infants were prospectively enrolled. Preterm infants exhibited prolonged N1 latencies, central conduction times (CCTs), lower N1-P1 amplitudes, and more recurrently abnormal SEPs compared to term infants. Higher pain exposure predicted longer N1 latency and slower CCT (all p < 0.005), adjusting for clinical risk factors. Younger GA and postmenstrual age (PMA) at SEP recording were associated with longer N1 latency and lower N1-P1 amplitude (all p < 0.005). A normal SEP at TEA positively predicted cognitive outcome at 2 years CA (p < 0.005). Conclusion: Pain exposure and prematurity were risk factors for altered SEP parameters at TEA. SEPs predicted cognitive outcome. [ABSTRACT FROM AUTHOR] |
| Databáze: | Complementary Index |
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