Data from Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine Broaden Understanding of Temporal Lobe Epilepsy (Altered immune pathways in patients of temporal lobe epilepsy with and without hippocampal sclerosis).

Předmět:	TEMPORAL lobe epilepsy HIPPOCAMPAL sclerosis EPILEPSY CENTRAL nervous system diseases CENTRAL nervous system BRAIN diseases
Zdroj:	Pain & Central Nervous System Week; 7/5/2024, p312-312, 1p
Abstrakt:	A recent study conducted at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine has explored the immune pathways involved in temporal lobe epilepsy (TLE). The researchers analyzed RNA-seq data from TLE patients with and without hippocampal sclerosis (HS) to identify differentially expressed genes and construct regulatory networks. They found several immune-related genes, such as HSP90AA1 and SOD1, that were differentially expressed in TLE-HS patients. The study provides new insights into the pathogenesis of TLE and suggests that the SOX2-OT/miR-671-5p/SPP1 axis may be a potential therapeutic target for TLE-HS. [Extracted from the article]
Databáze:	Complementary Index
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