Reports Outline Life Science Study Results from Nagoya University (Braf V600e Promotes Anchorage-independent Growth but Inhibits Anchorage-dependent Growth In Htert / Cdk4-immortalized Normal Human Bronchial Epithelial Cells).

Předmět:	LIFE sciences EPITHELIAL cells BRAF genes SCIENCE journalism REPORTERS & reporting
Zdroj:	Cancer Weekly; 7/2/2024, p976-976, 1p
Abstrakt:	A study conducted by researchers at Nagoya University in Japan explores the effects of mutant BRAF V600E on normal human bronchial epithelial cells (HBEC3). The study found that mutant BRAF V600E enhances colony formation in anchorage-independent conditions but inhibits colony formation in anchorage-dependent conditions. This contrast may be due to differences in activation signaling in downstream pathways. The study also suggests that HBEC3 cells are inherently resistant to oncogene-induced senescence (OIS), possibly because the protein p21 remains localized in the cytoplasm upon expression of mutant BRAF V600E or KRAS V12. [Extracted from the article]
Databáze:	Complementary Index
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