| Abstrakt: |
A recent study conducted at Doshisha University explored the effects of hydroxyurea (HU) on DNA structure and gene expression. HU is a chemotherapy medication used to treat cancer and sickle cell anemia. The study found that HU had a bimodal effect on gene expression, promoting or inhibiting it at lower or higher concentrations, respectively. Additionally, the study revealed that HU directly interacts with DNA, causing changes in its higher-order structure. These findings provide new insights into the mechanisms of HU as a chemotherapeutic agent and its potential applications in treating other diseases. [Extracted from the article] |
