| Abstrakt: |
A recent study conducted at University Hospital Frankfurt in Germany explores the role of interferon-regulated expression of cellular splicing factors in HIV-1 gene expression and replication. The study highlights the importance of interferon-stimulated genes (ISGs) in restricting viral replication, as well as the lesser-known interferon-repressed genes (IRepGs) that affect the expression of host dependency factors necessary for efficient HIV-1 gene expression. The research specifically focuses on the impact of RNA-binding protein families, such as SRSF and hnRNP, on HIV-1 replication. The findings suggest that these proteins, regulated by interferon, play a role in innate immunity and its effect on HIV-1 replication. [Extracted from the article] |
