| Abstrakt: |
A new report discusses research findings on schizophrenia, a brain disorder with complex genetic and environmental causes. The study focuses on the striatum, a brain region implicated in the disorder, and examines cellular and molecular mechanisms using induced pluripotent stem cells (iPSCs) derived from individuals with schizophrenia. The researchers found differences in developmental trajectory and gene expression in inhibitory neurons derived from individuals with schizophrenia compared to neurotypical controls. These findings suggest that abnormalities in striatal neurons associated with schizophrenia originate during early brain development. The study provides insights into the neurodevelopmental aspects of schizophrenia using a novel model system. [Extracted from the article] |
