| Abstrakt: |
A recent study conducted at Tel Aviv University has found that myeloid cells, which infiltrate tumors, have the potential to elicit robust tumor-specific cytotoxicity. The researchers discovered that activating IgM-induced signaling in these cells resulted in the secretion of lytic granules and significant tumor cell death. However, the study also revealed that myeloid cells do not naturally express the antibody-derived portion used to recognize tumor antigens. To overcome this limitation, the researchers designed chimeric receptors based on the high-affinity FcgRI for IgG, which successfully induced tumor cell killing. This research provides insights into the challenges of genetically reprogramming myeloid cells and offers a framework for enhancing their antigen-specific cytotoxicity. [Extracted from the article] |
