| Autor: |
Baskar G., Keerthana K., Supriya A., Pravin R., Abinesh A. R., Yuvaraaj SA |
| Předmět: |
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| Zdroj: |
Indian Journal of Experimental Biology; Jun2024, Vol. 62 Issue 6, p393-399, 7p |
| Abstrakt: |
The focus on utilization of marine macroalgae for green synthesis of bimetallic nanoparticles with potential applications in cancer treatment has gained a lot of attention in recent years. In this present study, we synthesized a nanobiocomposite using the red pigment R-phycoerythrin from the marine red algae Porphyridium purpureum and explored its anticancer potential. This vibrant red fluorescent pigment plays a crucial role as a reducing and stabilizing agent. Ag-ZnO nanobiocomposite was synthesized by green approach using phycoerythrin as a capping agent. The synthesized nanobiocomposite was characterized using UV-Vis spectroscopy, XRD, FT-IR and SEM-EDX techniques. The obtained UV-Vis graph has confirmed the presence of Ag, Zn and phycoerythrin in the synthesized nanobiocomposite. The FT-IR showed the occurrence of Zn--O vibration peak along with hydroxyl and carboxyl groups. The XRD results confirmed the crystalline nature and hexagonal shape of the nanobiocomposite. The overall effect of the synthesized phycoerythrin-Ag-ZnO nanobiocomposite was studied by MTT assay to check its anticancer applications. From the obtained results, the IC50 value was found to be 100 µg against MCF-7 cell line. This confirms that the synthesized phycoerythrin-Ag-ZnO nanobiocomposite inhibited the growth of MCF-7 cell line and thus can be efficiently used as a photosensitive drug for chemotherapy in future. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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