| Autor: |
Abbasi, Arooba Noor, Qaiser, Syed Faiq, Hoda, Fatimah, Memon, Aaima, Lakho, Arooba |
| Předmět: |
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| Zdroj: |
Health Science Reports; Jun2024, Vol. 7 Issue 6, p1-7, 7p |
| Abstrakt: |
Background: This article explores the association between fractures, particularly in the elderly, and elevated plasma high‐density lipoprotein cholesterol (HDL‐C) levels. The study challenges the conventional idea of HDL‐C as "good cholesterol" by revealing its potential role as a risk factor for fractures. Factors contributing to fractures in the elderly, such as diminishing bone strength due to aging‐related tissue breakdown, are discussed. Sedentary lifestyles, low bone mineral density (BMD), and habits like smoking and alcohol consumption compound fracture susceptibility. Materials and Methods: The study delves into mechanisms linking elevated HDL‐C to fractures, using data from the ASPREE‐Fracturesub‐study of the ASPREE trial involving Australian and American participants aged 65 and above. Results: The study showed that over a 4‐year period, elevated HDL‐C levels in healthy older people were linked to a 14% higher fracture risk. This revelation expands the understanding of fracture risk factors beyond the established norms. Conclusion: The article emphasizes the need to reconsider HDL‐C's traditional role as an indicator of cardiovascular health, particularly in light of medications like Statins and Anacetrapib that raise HDL‐C levels. It calls for further exploration into the relationship between HDL‐C, fractures at varying sites, and different age groups. Practical implications involve incorporating fracture risk associated with high HDL‐C into clinical considerations, alongside advocating lifestyle changes for optimal HDL‐C levels. In summary, this study prompts a reevaluation of HDL‐C's implications in clinical practice, demanding further investigation into the intricacies of this relationship. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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