Unveiling Distinctive MRI Characteristics in the Diagnosis of GFAP Astrocytopathy: A Rare Autoimmune Neuroinflammatory Disorder.

Autor:	Charan, Bheru D., Priya, Shikha, Goel, Vinay, Chhatarpal, Pinky, Jain, Savyasachi, Gupta, Anu, Garg, Ajay
Předmět:	AUTOIMMUNE disease diagnosis WEIGHT loss VASCULITIS LEG RARE diseases MAGNETIC resonance imaging PREDNISOLONE RITUXIMAB CENTRAL nervous system FLUORESCENT antibody technique NEUROLOGICAL disorders MUSCLE weakness RETENTION of urine CENTRAL nervous system diseases CEREBROSPINAL fluid BIOMARKERS
Zdroj:	Annals of Indian Academy of Neurology; May/Jun2024, Vol. 27 Issue 3, p316-318, 3p
Abstrakt:	Glial fibrillary acidic protein (GFAP) astrocytopathy is a rare autoimmune inflammatory disorder affecting the central nervous system, involving the meninges, brain parenchyma, and spinal cord. The distinctive radiologic feature observed on magnetic resonance imaging (MRI) is characterized by periventricular radial and linear contrast enhancement. This case report details a 45-year-old male who initially exhibited constitutional symptoms, followed by encephalitis, lower limb weakness, and urinary retention. The MRI findings revealed meningoencephalitis with longitudinal extensive myelitis. Notably, the cerebrospinal fluid analysis confirmed the presence of anti-GFAP antibodies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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