Arylation of quinoxalinones at room temperature under metal and base free-conditions.

Autor: Badhani, Gaurav, Adimurthy, Subbarayappa
Zdroj: Chemical Monthly / Monatshefte für Chemie; Jun2024, Vol. 155 Issue 6, p613-619, 7p
Abstrakt: A mild and efficient method for the arylation of quinoxalinones are described using aryldiazonium tetrafluoroborates as aryl source. Reactions proceeds at room temperature in a short reaction time of 1 h without metal catalysts and bases. Broad functional group tolerance was observed with good yields of products even at gram scale reaction. Control experiments suggest that the reactions proceed through a radical pathway. Furthermore, the present protocol applied for the successive synthesis of three biologically active molecules. Overall, the method offers a convenient and versatile approach for the synthesis of arylated quinoxalinones. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index