| Autor: |
Fraser, Jre, Brown, T. J., Cahill, T. N. P, T. C.Laurent, Laurent, U. B. G. |
| Předmět: |
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| Zdroj: |
Immunology & Cell Biology; Apr1996, Vol. 74 Issue 2, special section pA10-A10, 1p |
| Abstrakt: |
This article discusses various issues related to the turnover of hyaluronan in synovial joints. Hyaluronan was found in synovial fluid shortly after its discovery in vitreous humor, and later shown to be the primary source of its remarkable visco-elastic behavior. This characteristic appears responsible for lubrication of the soft tissue lining of joints, though its role in lubrication of cartilage is not fully resolved. The viscosity of synovial effusions is lowered by reduction in both concentration and mean molecular weight of their hyaluronan content, which is nevertheless increased due to the increased fluid volume. Its synthesis is enhanced by a wide variety of agents incriminated in arthritis, such as activating peptides, growth factors and cytokines and its turnover may therefore reflect disease activity more directly than other indices of inflammation. |
| Databáze: |
Complementary Index |
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