| Autor: |
Bayramova, Aysel, Keçeci, Mete, Akpolat, Meryem, Cengil, Osman |
| Předmět: |
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| Zdroj: |
Reproduction, Fertility & Development; 2024, Vol. 36 Issue 10, p1-12, 12p |
| Abstrakt: |
Context: Carbon tetrachloride (CCl4) is a chemical that is still widely used in industry and has been shown to cause structural defects in rat testicles through oxidative stress. Aims: In our study, the effect of curcumin on CCl4-mediated testicular damage was investigated. Methods: Twenty-four adult Wistar albino male rats weighing 300–350 g were divided into four groups: control group (olive oil was applied by gavage every consecutive day for 3 weeks); curcumin and CCl4 + curcumin groups (200 mg/kg curcumin dissolved in olive oil was given by gavage once a day, every consecutive day for 3 weeks); and CCl4 and CCl4 + curcumin groups (0.5 mL/kg CCl4 was dissolved in olive oil at a ratio of 1/1 and given by i.p. injection every other day for 3 weeks). Tissue samples were examined histopathologically, histomorphometrically, immunohistochemically and biochemically. Key results: CCl4 disrupted both testicular morphology and testosterone synthesis, whereas curcumin treatment resulted in an improvement in testicular morphology and biochemical parameters, as well as a decrease in caspase-3 and tumour necrosis factor-α expression. Conclusions: Curcumin has a protective effect on testicular tissue damage caused by CCl4 with its anti-inflammatory, antiapoptotic and antioxantioxidant properties. Implications: Curcumin can prevent testicular damage due to CCl4, an environmental pollutant. Carbon tetrachloride (CCl4) is a chemical widely used in industry. Although CCl4 exposure has significant toxicity on the liver, there are also experimental studies showing that it causes testicular damage through oxidative stress. Curcumin is a powerful antioxidant nutraceutical. Our study showed that curcumin can prevent CCl4-mediated testicular injury with its antioxidant, anti-inflammatory and antiapoptotic properties. Illustration by Mete Keçeci. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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