Synthesis of functionalized organophosphorus analogs of β-phenylalanine.

Autor:	Bubnov, Yu. N., Prishchenko, A. A., Livantsov, M. V., Novikova, O. P., Livantsova, L. I., Baranin, S. V.
Předmět:	BIOACTIVE compounds HYDROPHILIC compounds ACID derivatives RADICALS (Chemistry) ORGANOPHOSPHORUS compounds
Zdroj:	Russian Chemical Bulletin; May2024, Vol. 73 Issue 5, p1374-1385, 12p
Abstrakt:	A convenient synthesis of organophosphorus analogs of β-phenylalanine containing functionalized 2-phenylethylphosphonous and 2-phenylethylphosphinic acid moieties has been developed. The radical addition of bis(trimethylsiloxy)phosphine to styrene, trimethylsilyl cinnamate, or arylacetylenes proceeds regioselectively to give a variety of substituted 2-phenylethylphosphonites, and the subsequent functionalization affords various derivatives of the target acids. The resulting compounds are of interest as promising biologically active compounds and water-soluble ligands. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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