| Autor: |
WANG Junling, ZHAN Mengmeng, GU Fangqiu, LI Yifei, ZHANG Zhaolong, ZHAO Congyi, ZHAO Danyang, ZHENG Hui, ZHANG Yijie, QIN Bingyu |
| Zdroj: |
Journal of Practical Medicine / Shiyong Yixue Zazhi; 6/10/2024, Vol. 40 Issue 11, p1513-1518, 6p |
| Abstrakt: |
Objective To investigate the effects of allergens on the expressions of IL-18, IL-18BPa and IL-18Rα protein in peripheral blood CD4+ Th1 cells of healthy control subjects (HC) and patients with allergic rhinitis (AR), and on the expressions of IL-18, IL-18BPa and IL-18Rα mRNA in the peripheral blood CD4+ T cells. Methods Blood samples were collected from patients with rhinitis for negative skin prick test (AR-), rhinitis for positive skin prick test (AR+) and HC. Flow cytometry was used to evaluate the effects of allergens on the expressions of IL-18, IL-18BPa and IL-18Rα protein in CD4+ Th1 cells. The expressions of IL-18, IL-18BPa and IL-18Rα mRNA in CD4+ T cells were determined by qPCR. Results Compared with HC, increased IL-18 while decreased IL-18BPa expressions in Th1 cells of AR- and AR+ patients were observed, increased IL-18Rα expression in Th1 cells of AR+ patients was also found. Additionally, allergens induced elevated expression of IL-18Rα protein in Th1 cells of HC, and induced elevated mRNA expressions of IL-18, IL-18BPa and IL-18Rα in isolated blood CD4+ T cells of AR+ patients and HC. Conclusion Allergens may be involved in the pathogenesis of AR by inducing the expressions of IL-18 and IL-18Rα in blood CD4+ Th1 cells. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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