Study Findings from Trinity Biomedical Sciences Institute Update Knowledge in Interferons (Early interferon lambda production is induced by double-stranded RNA in iPS-derived hepatocyte-like cells).

Předmět:	MEDICAL sciences DOUBLE-stranded RNA INTERFERONS PATTERN perception receptors GENE expression
Zdroj:	Gastroenterology Week; 6/24/2024, p803-803, 1p
Abstrakt:	A recent study conducted by Trinity Biomedical Sciences Institute in Dublin, Ireland, explored the early production of interferon lambda (IFNL) in hepatocyte-like cells (HLCs) in response to viral-like RNA. The researchers found that HLCs rely on cytoplasmic pattern recognition receptors (PRRs) to detect double-stranded RNA and mount an innate antiviral response. The study also demonstrated that HLCs induce type III interferon gene expression to a greater extent than type I interferon expression. These findings contribute to our understanding of the innate defense responses of hepatocytes to hepatotropic viruses. [Extracted from the article]
Databáze:	Complementary Index
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