Investigators from University of Yaounde I Zero in on Malaria (Phenotypic Changes of Gd T Cells In plasmodium Falciparum Placental Malaria and Pregnancy Outcomes In Women At Delivery In Cameroon).

Předmět:
Zdroj: Zika & Mosquito Week; 6/28/2024, p20-20, 1p
Abstrakt: A recent study conducted in Yaounde, Cameroon investigated the relationship between gamma delta T cell phenotype change and Placental Malaria (PM) with pregnancy outcomes. The study found that placental Plasmodium falciparum infection was associated with an increase in the frequency of total gamma delta T cells and the V delta 1(+) subset, but a decrease in the frequency of the V delta 2(+) subset. The expression of activation and exhaustion markers within gamma delta T cells and subsets were also up-regulated in PM-positive women. These findings suggest that activated and exhausted gamma delta T cells play a role in Plasmodium falciparum placental malaria and can impact pregnancy outcomes such as maternal hemoglobin levels and birth weight. [Extracted from the article]
Databáze: Complementary Index