| Abstrakt: |
A new study conducted by researchers at McGill University has found that the neuromodulatory subcortical nuclei within the isodendritic core (IdC) are the earliest sites of tauopathy in Alzheimer's disease (AD). The researchers used multiparametric quantitative magnetic resonance imaging to investigate the relationship between IdC microstructure and whole-brain white matter microstructure in older adults with familial risk for AD. They observed two covariance patterns between IdC and white matter microstructure, with one pattern specifically associated with AD. The study suggests that IdC microstructure variation is reflected in white matter, particularly in AD-affected tracts, and highlights an early mechanism of pathological development in AD. [Extracted from the article] |
