| Abstrakt: |
A recent study conducted by Maseno University in Kenya examined the entire expressed peripheral blood transcriptome in pediatric severe malarial anemia (SMA). The study compared the transcriptome between Kenyan children with non-SMA and SMA, revealing impairments in host inflammasome activation, cell death, and innate immune and cellular stress responses in SMA. The research also identified disruptions in cellular homeostasis and regulatory pathways, as well as activation in response to hypoxic conditions, as central themes in SMA. These findings provide insights into the molecular mechanisms of SMA and offer potential targets for new malaria therapies. [Extracted from the article] |
