Fat molecule's inability to bond with shape-shifting protein in cell's powerhouse linked to an inherited metabolic disease.

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Zdroj: Genomics & Genetics Weekly; 6/24/2024, p247-247, 1p
Abstrakt: A recent study conducted by scientists at Johns Hopkins Medicine has found that the biochemical bonds between fats and proteins in the mitochondrion, the cell's powerhouse, are crucial for energy production in cells. The researchers focused on the interaction between cardiolipin, a fatty compound, and proteins that transport adenosine triphosphate (ATP), an energy molecule. They discovered that disruptions in these interactions weaken the structure and function of the proteins, leading to a breakdown in the energy production process. This research provides new insights into metabolic diseases such as Barth syndrome and could potentially lead to the development of new therapeutic targets. [Extracted from the article]
Databáze: Complementary Index