| Předmět: |
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| Zdroj: |
Immunotherapy Weekly; 6/25/2024, p1165-1165, 1p |
| Abstrakt: |
A recent study conducted at Leiden University Medical Center in the Netherlands explored the impact of belimumab therapy on memory B-cell trafficking in patients with systemic lupus erythematosus (SLE). The researchers conducted a retrospective meta-analysis and performed extensive phenotyping and transcriptomic characterization of memory B cells in patients with SLE. The study found that belimumab treatment led to a significant increase in circulating memory B cells, particularly in patients with higher disease activity. These memory B cells exhibited a non-proliferating phenotype and demonstrated disrupted lymphocyte trafficking. This research expands our understanding of the therapeutic mechanism of belimumab in SLE. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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