A Study on Haematological and Coagulation Parameters in Newly Diagnosed Tuberculosis Patients.

Autor: Kumaravel, Ashwinamurthy, Jadhav, Priyanka nimbalkar, Sahu, Shilpi, Athavale, Akshay, Vipul Joshi, Riddhi, Singh, Arpita, Samuel, Stanley Johnson
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Zdroj: European Journal of Cardiovascular Medicine; 2024, Vol. 14 Issue 2, p916-922, 7p
Abstrakt: Introduction: Tuberculosis (TB) is the most prevalent infectious disease which is brought by the mycobacterium tuberculosis. In addition to the lung tissue, TB also affects the bone marrow. Significant haematological and coagulation abnormalities are associated with TB. Therefore the diagnosis, prognosis, and therapeutic response can also be indicated by these haematological and coagulation markers. These coagulation abnormalities can lead to stroke and DIC leading to increased mortality. Aims To evaluate the haematological and coagulation parameters in pulmonary tuberculosis patients. Methods and Materials: In this study a total of 50 patients with confirmed tuberculosis were chosen using purposive sampling. Four millilitres of venous blood were drawn while taking the necessary aseptic precaution. Sysmex XN 1000 6-part haematology analyser was used to perform hematologicalanalysis on two millilitres of ethylenediamine tetra acetic acid (EDTA)vacutainer tubes. Rest two millilitres of blood in sodium citrate vacutainer tube was used to perform coagulation parameters analysis on ACL elite pro coagulation analyser for measurement of D dimer and fibrinogen. Results Hemoglobin and other blood indices were marginally lower in both sexes compared to healthy controls. Patients with tuberculosis show significantly greater levels of white blood cells (WBC), platelets, D-dimer, and fibrinogen when compared to healthy controls. P-value < 0.05 indicated that these increases were statistically significant. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index