| Autor: |
Martino Cinnera, Alex, Bonanno, Mirjam, Calabrò, Rocco Salvatore, Bisirri, Alessio, D'Arienzo, Martina, D'Acunto, Alessia, Ciancarelli, Irene, Morone, Giovanni, Koch, Giacomo |
| Předmět: |
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| Zdroj: |
Expert Review of Medical Devices; Jun2024, Vol. 21 Issue 6, p507-518, 12p |
| Abstrakt: |
Spinal cord injuries (SCI) often result in motor impairment and lifelong disability. This systematic review, conducted in agreement with PRISMA guidelines, aimed to evaluate the effects of cortico-spinal paired associative stimulation (PAS) on motor outcomes in individuals with SCI. PubMed, Scopus/EMBASE, Pedro, and Cochrane databases were consulted from inception to 2023/01/12. In 1021 articles, 10 studies involving 84 patients meet the inclusion criteria, 7 case series/study, and 3 clinical trials. Despite light differences, the included studies performed a cortico-peripheral PAS using a single transcranial magnetic stimulation and high frequency electrical peripheral nerve stimulation for a consistent number of sessions (>20). All included studies reported improvement in motor outcomes recorded via clinical and/or neurophysiological assessment. Available evidence showed an increase in motor outcomes after PAS stimulation. Indeed, both clinical and neurophysiological outcomes suggest the effectiveness of a high number of PAS sessions in chronic individuals with SCI. Due to a limited number of studies and an unsatisfactory study design, well-designed RCTs are needed to confirm the potentiality of these approaches and clarify the adequate dose-response of PAS in the SCI population. The protocol was registered on the PROSPERO database (CRD42023485703). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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