Search for linkage disequilibrium between alleles in the T cell receptor α and β chain loci and susceptibility to rheumatic fever.

Autor:	Abbott, W. G. H., Geursen, A., Peake, J. S., Simpson, I. J., Skinner, M. A., Tan, P. L. J.
Předmět:	T cell receptors RHEUMATIC fever MAORI (New Zealand people) CELL receptors RHEUMATISM COLLAGEN diseases
Zdroj:	Immunology & Cell Biology; Aug1995, Vol. 73 Issue 4, p369-371, 3p
Abstrakt:	A population-based linkage disequilibrium study was conducted to search for associations between alleles in T cell receptor α and β chain polymorphic loci and susceptibility to rheumatic fever. The allele frequencies of four T cell receptor locus restriction fragment length polymorphisms were measured in 47 European and 51 Maori subjects with a history of rheumatic fever. These allele frequencies were compared to the allele frequencies in three or four independently recruited, race-matched control groups totalling 125 Europeans and 117 Maoris with no history of rheumatic fever. The polymorphisms studied were (locus/enzyme/probe) Cα/Taq1/Y14, Vα/Taq1/Y14, /BAMHI/V㬧.4 and Vβ8/BAMHI/Vβ8.1. There was no evidence for linkage disequilibrium between rheumatic fever and these Tcr alleles in either the Maori or European subjects [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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