| Autor: |
Rosberg, Aylin, Merisaari, Harri, Lewis, John D., Hashempour, Niloofar, Lukkarinen, Minna, Rasmussen, Jerod M., Scheinin, Noora M., Karlsson, Linnea, Karlsson, Hasse, Tuulari, Jetro J. |
| Zdroj: |
BMC Medicine; 3/25/2024, Vol. 22 Issue 1, p1-9, 9p, 1 Black and White Photograph, 1 Diagram, 3 Charts, 1 Graph |
| Abstrakt: |
Background It is well-established that parental obesity is a strong risk factor for ofspring obesity. Further, a converging body of evidence now suggests that maternal weight profles may afect the developing ofspring’s brain in a manner that confers future obesity risk. Here, we investigated how pre-pregnancy maternal weight status infuences the reward-related striatal areas of the ofspring’s brain during in utero development. Methods We used difusion tensor imaging to quantify the microstructure of the striatal brain regions of interest in neonates (N=116 [66 males, 50 females], mean gestational weeks at birth [39.88], SD=1.14; at scan [43.56], SD=1.05). Linear regression was used to test the associations between maternal pre-pregnancy body mass index (BMI) and infant striatal mean difusivity. Results High maternal pre-pregnancy BMI was associated with higher mean MD values in the infant’s left caudate nucleus. Results remained unchanged after the adjustment for covariates. Conclusions In utero exposure to maternal adiposity might have a growth-impairing impact on the mean difusivity of the infant’s left caudate nucleus. Considering the involvement of the caudate nucleus in regulating eating behavior and food-related reward processing later in life, this fnding calls for further investigations to defne the prognostic relevance of early-life caudate nucleus development and weight trajectories of the ofspring [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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