| Autor: |
LaCourse, Sylvia M, Wetzler, Erica A, Aurelio, Morgan C, Escudero, Jaclyn N, Selke, Stacy S, Greninger, Alexander L, Goecker, Erin A, Barnes, Sarina R, Arnould, Isabel S, Pérez-Osorio, Ailyn C, Richardson, Barbra A, Kachikis, Alisa, Englund, Janet A, Drake, Alison L |
| Předmět: |
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| Zdroj: |
Journal of Infectious Diseases; 6/15/2024, Vol. 229 Issue 6, p1728-1739, 12p |
| Abstrakt: |
Background Hybrid immunity (infection plus vaccination) may increase maternally derived SARS-CoV-2 antibody responses and durability versus infection alone. Methods Prospective cohort of pregnant participants with prior SARS-CoV-2 infection (anti-nucleocapsid IgG, RT-PCR, or antigen positive) and their infants had blood collected in pregnancy, at delivery/birth, and postpartum tested for anti-spike (anti-S) IgG and neutralizing antibodies (neutAb). Results Among 107 participants at enrollment, 40% were unvaccinated and 60% were vaccinated (received ≥1 dose); 102 had previous SARS-CoV-2 infection in pregnancy (median, 19 weeks' gestation); 5 were diagnosed just prior to pregnancy (median, 8 weeks). At delivery, fewer unvaccinated participants (87% anti-S IgG+, 86% neutAb) and their infants (86% anti-S IgG+, 75% neutAb) had anti-S IgG+ or neutAb compared to vaccinated participants and their infants (100%, P ≤.01 for all). By 3–6 months postpartum, 50% of infants of unvaccinated participants were anti-S IgG+ and 14% had neutAb, versus 100% among infants of vaccinated participants (all P <.01), with lower median antibody responses (anti-S IgG log10 1.95 vs 3.84 AU/mL, P <.01; neutAb log10 1:1.34 vs 1:3.20, P =.11). Conclusions In pregnant people with prior SARS-CoV-2, vaccination before delivery provided more durable maternally derived antibody responses than infection alone in infants through 6 months. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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