Dynamics and Clinical Significance of Cytomegalovirus-Specific Neutralizing Antibodies in Kidney Transplant Recipients Treated with T-Cell–Depleting Agents.

Autor: Fernández-Ruiz, Mario, García-Ríos, Estéfani, Redondo, Natalia, Rodríguez-Goncer, Isabel, Ruiz-Merlo, Tamara, Parra, Patricia, Sandonis, Virginia, López-Medrano, Francisco, Juan, Rafael San, González, Esther, Polanco, Natalia, Andrés, Amado, Navarro, David, Aguado, José María, Pérez-Romero, Pilar
Předmět:
Zdroj: Journal of Infectious Diseases; 6/15/2024, Vol. 229 Issue 6, p1812-1816, 5p
Abstrakt: We measured cytomegalovirus (CMV)-specific antibodies that neutralize epithelial cell infection (CMV-AbNEIs) in 101 CMV-seropositive kidney transplant recipients (KTRs) at baseline and posttransplant months 3 and 6. All the patients received antithymocyte globulin and 3-month valganciclovir prophylaxis. There were no significant differences in pretransplant AbNEIs titers between KTRs that developed or did not develop any-level CMV infection or the composite of high-level infection and/or disease. One-year CMV infection-free survival was comparable between KTRs with or without pretransplant CMV-AbNEIs. No differences were observed by months 3 and 6. We observed no protective role for CMV-AbNEIs among CMV-seropositive KTRs undergoing T-cell–depleting induction. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index