| Autor: |
Bag, S. S., Banerjee, A., Sinha, S. |
| Předmět: |
|
| Zdroj: |
Synlett; Jul2024, Vol. 35 Issue 11, p1195-1227, 33p |
| Abstrakt: |
This article explores the expansion of the genetic alphabet through the creation of unnatural nucleobase pairs. These new nucleobase pairs can be incorporated into DNA, allowing for the generation of unique functional proteins. The article discusses the development of xeno-nucleic acids (XNAs) and the use of charge-transfer interactions and click chemistry to design synthetic nucleobases. It also explores the synthesis and potential applications of C-nucleosides, as well as the design and applications of unnatural nucleobases in DNA and RNA. The researchers successfully created a semi-synthetic organism with an expanded genetic alphabet and investigated the stability and pairing selectivity of abasic DNA duplexes containing unnatural nucleobases. The article also discusses the use of fluorescent nucleosides in detecting DNA lesions and the potential applications of chimeric DNA duplexes in various fields. The research provides valuable insights for researchers interested in genetic alphabet expansion and the study of nucleic acids and proteins. [Extracted from the article] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
