Fertility and Pregnancy-Related Issues in Young BRCA Carriers With Breast Cancer.

Autor:	Magaton, Isotta Martha, Arecco, Luca, Mariamidze, Elene, Jankovic, Kristina, Stana, Mihaela, Buzzatti, Giulia, Trevisan, Lucia, Scavone, Graziana, Ottonello, Silvia, Fregatti, Piero, Massarotti, Claudia, von Wolff, Michael, Lambertini, Matteo
Předmět:	THERAPEUTIC use of antineoplastic agents FERTILITY BRCA genes BREAST tumors ANTINEOPLASTIC agents WOMEN'S health OVARIAN reserve GENETIC mutation
Zdroj:	Breast Cancer: Basic & Clinical Research; 6/14/2024, p1-10, 10p
Abstrakt:	Approximately 10% to 15% of breast cancer cases in young women are diagnosed in patients harbouring germline (g) pathogenic or likely pathogenic variants (PVs) in the BReast CAncer 1 (BRCA1) or BReast CAncer 2 (BRCA2) genes. Preclinical and clinical studies showed a potential negative effect of germline BRCA 1/2 (g BRCA1/2) PVs on ovarian reserve and reproductive potential, even before starting anticancer therapies. The aim of this article is to summarize the current literature on the fertility potential of young g BRCA1/2 PVs carriers with breast cancer and the risk of gonadotoxicity associated with anticancer treatments. Moreover, we describe the available evidence on the efficacy of fertility preservation techniques in young g BRCA1/2 PVs carriers and the safety data on having a pregnancy after breast cancer treatment. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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