| Autor: |
Sriyani, Maula Eka, Widyasari, Eva Maria, Yulianti, Fifi Lifia, Sihombing, Zico Daniel Despen, Elisa, Clara, Halimah, Iim, Febrian, M. Basit, Wibawa, Teguh Hafidz Ambar, Setiadi, Yanuar |
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| Zdroj: |
AIP Conference Proceedings; 2024, Vol. 3074 Issue 1, p1-6, 6p |
| Abstrakt: |
Pyrimethamine is a drug used in the treatment of toxoplasmosis. In labeled compounds for the diagnosis and therapy of toxoplasmosis development, it is necessary to select a labeling method to determine the structure of products. The iodination of pyrimethamine in this research uses non-radioactive iodine. The method used in this research is the oxidation method using chloramine-T at room temperature. White powder soluble in water or DMSO is obtained as a product. There was a change in color at a temperature of 260°C, did not melt until a temperature> 290°C. Observation under a microscope looks like a rod-shaped crystal. Strong absorption saw at a wavelength of 616.96 cm−1 in the FTIR spectra, which is typical for the C-I bond. The other absorptions also obtained at wavelength of 3300-3500 cm−1 (primary N-H bonds); 2970.07 cm−1 (C-C and C-H bonds); 1531.54 cm−1 (C=C bond); 1648.42 cm-1 (C=N bond); 1103.53 cm-1 (C- N bond); and 811.17 cm−1 (C-Cl bond). Based on the result, the oxidation method is the potential for the iodination of pyrimethamine. This research still needs to be supplemented with NMR, MS data, and further observations regarding the crystal structure. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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