| Autor: |
Motamedi, Melika, Xiao, Maggie Z.X., Deschenes, Jean, Hardin, Jori, Sterrett, Russell, Street, Lesley, Taparia, Minakshi, Mahe, Etienne, Ferrara, Giovanni, Barrie, James R., Gniadecki, Robert |
| Předmět: |
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| Zdroj: |
Dermatology (10188665); 2024, Vol. 240 Issue 3, p468-473, 6p |
| Abstrakt: |
Background: Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate. Objective: The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there have been both favorable and unfavorable outcomes documented. Methods: We performed a systematic review of 116 GMF cases previously described in the literature. Results: In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months. Conclusion: GMF is an aggressive form of MF. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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