| Autor: |
Veeramani, Karuna, Shinde, Manish, Eda, Vishnuvardhana Vema Reddy, Peraka, Swamy, Mohan, Saranya, Bandichhor, Rakeshwar, Oruganti, Srinivas |
| Předmět: |
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| Zdroj: |
Journal of Flow Chemistry; Jun2024, Vol. 14 Issue 2, p481-489, 9p |
| Abstrakt: |
Myristyl-γ-picolinium chloride (MGPC) is an alkyl pyridine quaternary ammonium salt and a popular preservative in injectables such as Depo-Medrol (Methylprednisolone acetate). Herein we describe a successful high-p,T,c chemical intensification of MGPC synthesis from neat myristyl chloride and γ-picoline in continuous flow. The process is atom economical, scalable with low reactor footprint and under optimized conditions, consistently affords MGPC in 45 min (instead of 8–12 h reported in literature for a conventional batch process) with excellent yield (> 90%) and purity (> 99%). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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