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Simple Summary: Radionuclide bone imaging, which reflects osteoblastic activity, is used in evaluating cartilaginous bone tumors; higher SUVmax is more indicative of an ACT rather than an enchondroma in SPECT/CT. However, SUVmax can be influenced by several factors, including radiodensity. Therefore, this study was designed to correlate radiodensity measurements with SUVmax of central cartilaginous bone tumors, including enchondroma, and low-to-intermediate grade chondrosarcomas. Our findings revealed a significant negative correlation between SUVmax and radiodensity measurements in HUmax, HUmean, and HUSD. The subgroup analysis showed significantly higher SUVmax and lower HUSD in the malignant group (grade 1 and 2 chondrosarcoma) than in the benign group (enchondroma). It was observed that higher SUVmax and lower HUSD were associated with a higher probability of having a low-to-intermediate grade chondrosarcoma with aggressive features and a less calcified tumor matrix. (1) Background: it is challenging to determine the accurate grades of cartilaginous bone tumors. Using bone single photon emission computed tomography (SPECT)/computed tomography (CT), maximum standardized uptake value (SUVmax) was found to be significantly associated with different grades of cartilaginous bone tumor. The inquiry focused on the effect of the tumor matrix on SUVmax. (2) Methods: a total of 65 patients from 2017 to 2022 with central cartilaginous bone tumors, including enchondromas and low-to-intermediate grade chondrosarcomas, who had undergone bone SPECT/CT were retrospectively enrolled. The SUVmax was recorded and any aggressive CT findings of cartilaginous bone tumor and Hounsfield units (HU) of the chondroid matrix as mean, minimum, maximum, and standard deviation (SD) were reviewed on CT scans. Pearson's correlation analysis was performed to determine the relationship between CT features and SUVmax. Subgroup analysis was also performed between the benign group (enchondroma) and the malignant group (grade 1 and 2 chondrosarcoma) for comparison of HU values and SUVmax. (3) Results: a significant negative correlation between SUVmax and HU measurements, including HUmax, HUmean, and HUSD, was found. The subgroup analysis showed significantly higher SUVmax in the malignant group, with more frequent CT aggressive features, and significantly lower HUSD in the malignant group than in the benign group. (4) Conclusions: it was observed that higher SUVmax and lower HUSD were associated with a higher probability of having a low-to-intermediate chondrosarcoma with aggressive features and a less calcified tumor matrix. [ABSTRACT FROM AUTHOR] |
