New Study Findings from University of North Carolina Chapel Hill Illuminate Research in Antisense Technology (Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the...).

Předmět:	REGIONALISM (International organization) RHESUS monkeys DEVELOPMENTAL disabilities BIOENGINEERING NEURON development
Zdroj:	Mental Health Weekly Digest; 6/21/2024, p1105-1105, 1p
Abstrakt:	A new study from the University of North Carolina Chapel Hill explores the regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey. The research focuses on Angelman syndrome (AS), a neurogenetic disorder caused by mutations or deletions in the maternally-inherited UBE3A allele. The study found that UBE3A is silenced in neurons during development by a noncoding transcript, and the absence of UBE3A results in severe neurological symptoms. The findings suggest that early-life intervention may be optimal for overcoming the loss of UBE3A linked to AS. [Extracted from the article]
Databáze:	Complementary Index
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