Gut Microbiota Dysbiosis and Sleep Disorders: Culprit in Cardiovascular Diseases.

Autor: Pala, Barbara, Pennazzi, Laura, Nardoianni, Giulia, Fogacci, Federica, Cicero, Arrigo F. G., Di Renzo, Laura, Barbato, Emanuele, Tocci, Giuliano
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Zdroj: Journal of Clinical Medicine; Jun2024, Vol. 13 Issue 11, p3254, 14p
Abstrakt: Background: Over the past decade, the gut microbiome (GM) has progressively demonstrated to have a central role in human metabolism, immunity, and cardiometabolic risk. Likewise, sleep disorders showed an impact on individual health and cardiometabolic risk. Recent studies seem to suggest multi-directional relations among GM, diet, sleep, and cardiometabolic risk, though specific interactions are not fully elucidated. We conducted a systematic review to synthesize the currently available evidence on the potential interactions between sleep and GM and their possible implications on cardiometabolic risk. Methods: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement for reporting systematic reviews and meta-analyses, including articles from January 2016 until November 2022. Narrative syntheses were employed to describe the results. Results: A total of 8 studies were selected according to these criteria. Our findings indicated that the sleep disorder and/or the acute circadian rhythm disturbance caused by sleep–wake shifts affected the human GM, mainly throughout microbial functionality. Conclusions: Sleep disorders should be viewed as cardiovascular risk factors and targeted for preventive intervention. More research and well-designed studies are needed to completely assess the role of sleep deprivation in the multi-directional relationship between GM and cardiometabolic risk. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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