New Genetics Study Findings Have Been Reported by a Researcher at University of California (Site-specific regulation of RNA editing with ribose-modified nucleoside analogs in ADAR guide strands).

Předmět:	RNA regulation RNA editing GENETICS RESEARCH personnel POLY ADP ribose RNA synthesis
Zdroj:	Drug Week; 6/21/2024, p1739-1739, 1p
Abstrakt:	A recent genetics study conducted at the University of California in Davis has found that Adenosine Deaminases Acting on RNA (ADARs) enzymes can be used to correct disease-causing mutations in RNA. The study focused on the use of guide RNAs (gRNAs) to direct the ADAR reaction to specific sites. The researchers discovered that chemical modifications of the ADAR guide strands, such as ribose modifications, can increase the efficiency and selectivity of the editing reaction. This research sheds light on the mechanism of ADAR deamination and can aid in the design of highly selective ADAR guide strands for therapeutic editing using chemically modified RNA. [Extracted from the article]
Databáze:	Complementary Index
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