| Abstrakt: |
A new report from the Second Affiliated Hospital of Harbin Medical University explores the role of inflammation and dysregulated immunity in idiopathic pulmonary arterial hypertension (IPAH). The study utilized transcriptomic data from lung tissues of IPAH patients and controls to identify inflammation-associated hub genes. Through bioinformatics analysis, the researchers identified CXCL9, CCL5, GZMA, and GZMK as hub genes that distinguished IPAH patients from controls. Further investigation revealed that CCL5 and GZMA were highly expressed in T and NK cells, mediating their interaction with vascular cells. This study provides insights into a new inflammatory pathway in IPAH and lays the groundwork for targeted therapeutics. [Extracted from the article] |
