Synthesis, characterization and in vitro antiproliferative effects of isosteviol derivatives.
| Autor: | Qi, Xin-Xin, Wang, Pan-Pan, Cui, Lan-Tian, Jin, Mei, Zhao, Long-Xuan, Li, Gao |
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| Předmět: |
IN vitro studies
CERVIX uteri tumors GEFITINIB NUCLEAR magnetic resonance spectroscopy RESEARCH funding TERPENES ANTINEOPLASTIC agents CELL proliferation PLANT extracts CELL lines DOSE-effect relationship in pharmacology INFRARED spectroscopy MOLECULAR structure DATA analysis software ANALYTICAL chemistry techniques PHARMACODYNAMICS |
| Zdroj: | Journal of Asian Natural Products Research; Jul2024, Vol. 26 Issue 7, p812-823, 12p |
| Abstrakt: | Nineteen isosteviol derivatives were designed and synthesized by C-16, C-19 and D-ring modifications of isosteviol. These compounds were screened for their cytotoxic activities against Hela and A549 cells in vitro. Among them, the inhibitory effect of compounds 3b and 16 on Hela cells was comparable to that of the positive control gefitinib, and the compounds 3b (IC |
| Databáze: | Complementary Index |
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