| Abstrakt: |
We aimed to investigate the effectiveness of a dietary supplement containing DHA-PC, DHA, and EPA derived from salmon roe oil on ocular function and quality of life (QOL) in healthy adults who regularly experience eye dryness or fatigue due to aging or lifestyle. We conducted a randomized, double-blind, placebo-controlled, parallel-group study with 44 participants aged between 40 and less than 70 years. They were randomly assigned to receive either the test supplement or a placebo daily for 12 weeks. The daily test supplement contained salmon roe oil (DHA-PC 80mg, DHA 150mg, and EPA 60mg). The primary outcomes were subjective and objective dry eye pathology, assessed using subjective indicators from questionnaires (J-OSDI, DEQS) and objective indicators like BUT and Schirmer's test. Secondary outcomes included ocular accommodation, computer vision syndrome score, total cholesterol, HDL-C, LDL-C, and blood cortisol levels, as well as health questionnaires on stress and fatigue (PHRFSCL-SF), sensitivity to cold, and skin condition. The J-OSDI total score, ocular symptom score, and environmental factor score were significantly reduced in the test supplement group compared to the placebo group. While the DEQS summary score did not show statistical significance, the test supplement group exhibited a lower score than the placebo group. No inter-group differences were observed in the BUT and Schirmer's test. The fatigue body response score significantly decreased and improved in the test supplement group compared to the placebo group. We demonstrated that continuous use of the dietary supplement containing DHA- PC, DHA, and EPA derived from salmon roe oil for 12 weeks improved subjective symptoms associated with ocular dryness. [ABSTRACT FROM AUTHOR] |
